According to historians, pandemics typically have two types of endings: the medical, which occurs when the incidence and death rates plummet, and the social, when the epidemic of fear about the disease wanes. Among the diseases to have achieved a medical end is smallpox, which has an effective vaccine that gives lifelong protection. Bubonic plague struck several times in the past 2, years, killing millions of people and altering the course of history, but cases are now rare. An end can also occur not because a disease has been vanquished but because people grow tired of panic mode and learn to live with a disease. Jeremy Greene, a historian of medicine at Johns Hopkins. The flu killed 50 million to million people worldwide, preying on young to middle-aged adults — orphaning children, depriving families of breadwinners, killing troops in the midst of World War I.
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